Table 2.

Analysis of applying best and previously published cutoff points of urinary [TIMP 2]*[IGFBP7] for the prediction of AKI KDIGO 2/3

	AUC	Cut-Off	Sensitivity	Specificity	Youden’s index
4 h after surgery	0.646	0.185	0.75	0.56	0.31
		0.3	0.38	0.67	0.05
		2.0	0.13	1.0	0.13
Day 1 after surgery	0.971	1.0	1.0	0.9	0.9
		0.3	1.0	0.55	0.55
		2.0	0.67	0.95	0.62
Maximum early valuea	0.869	0.91	0.88	0.83	0.71
		0.3	0.88	0.48	0.36
		2.0	0.5	0.93	0.43

AKI acute kidney injury, AUC Area under the curve, IGFBP7 insulin-like growth factor binding protein 7, KDIGO Kidney Disease: Improving Global Outcomes, RRT renal replacement therapy, TIMP-2 tissue metalloproteinase 2

^adefined as maximum level in the first 24 h after surgery