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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Genomics. 2016 May 13;107(6):267–273. doi: 10.1016/j.ygeno.2016.05.002

Figure 1.

Figure 1

HyCCAPP workflow diagram. Gene expression for yeast cells grown under glucose or galactose is measured to help identify relevant regions for HyCCAPP experiments. Cells are crosslinked, harvested and the chromatin is purified using gradient ultracentrifugation. MS is used to identify proteins in the chromatin and in samples resulting from the HyCCAPP process. Both general chromatin-associated proteins and HyCCAPP-captured proteins that are enriched under one of the two growth conditions are identified. Glc, glucose; Gal, galactose; XL, crosslinked; GP, gradient purification.