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. Author manuscript; available in PMC: 2017 May 22.
Published in final edited form as: J Mol Biol. 2016 Apr 20;428(10 Pt B):2228–2236. doi: 10.1016/j.jmb.2016.04.018

Fig. 2.

Fig. 2

Interactions of E. coli RF1 with the ribosome and rearrangement of L27 upon RF1 binding. (a) Comparison of the PxT codon-recognition domains of E. coli (PAT, left; current work) and T. thermophilus RF1 (PVT, right; PDB ID: 4V63, [11]). (b) Comparison of the GGQ regions of RF1 from E. coli (left, current work) and T. thermophilus (right; PDB ID: 4V63, [11]) in the peptidyl-transferase center. Interactions of H236 are shown. (c) Rearrangement of L27 upon binding of RF1. L27 in the presence of RF1 (left; this work); L27 from the 70S ribosome with a vacant A site (right; PDB ID: 4W2H, [33]) in the absence of RF1.