Table 1.
Characteristics of included studies
| First author, year of publication | Design | Indication for PCI | PCI technique | Cut-off for low FFR - group | FFR technique | Definition of MACE | |
|---|---|---|---|---|---|---|---|
| Adenosine | Pressure wire pullback | ||||||
| Bech et al., [18] | Retrospective | Stable angina | POBA | <0.9 | i.v. | NA | MACE (death, MI, recurrent angina, CABG, repeated PTCA) |
| Pijls et al., [31] | Prospective, observational | All comers | “stent” (type NA) | ≤ 0.9 | i.v. or i.c. | No | MACE (death, MI, CABG, TVR) |
| Klauss et al., [30] | Retrospective | Stable angina | BMS | < 0.95 | i.c. | Not mandatory | MACE (death, MI, TVR) |
| Nam et al., [19] | Retrospective | 2/3 ACS, 1/3 stable angina | DES | ≤ 0.9 | i.c. | No | MACE (death, MI, TVR) |
| Leesar et al., [9] | Prospective, interventional | Stable angina | DES > BMS | < 0.96 | i.c. | No | MACE (death, MI, TLR) |
| Ito et al., [23] | Retrospective | 92 % stable angina, 8 % unstable angina | DES plus IVUS | ≤ 0.9 | i.c. | No | MACE (cardiac death, MI, TVR, stent thrombosis) |
| Reith et al., [24] | Prospective, observational | Stable angina | DES > BMS plus OCT | ≤ 0.905 | i.c. | No | MACE (death, MI, TLR) |
| Doh et al., [22] | Prospective, observational | 1/3 ACS, 2/3 stable angina | DES plus IVUS | < 0.89 | i.v. or i.c. | Not mandatory | TVF (death and MI attributed to target vessel, TVR) |
Abbreviations: ACS acute coronary syndrome, AUC area under curve, BMS bare metal stent, CABG coronary artery bypass graft, CI confidence interval, DES drug eluting stent, i.c. intracoronary, i.v. intravenous, IVUS intravascular ultrasound, FFR fractional flow reserve, FU follow up, MACE major adverse cardiac events, MI myocardial infarction, Mo months, N patient number, NA not applicable, OCT optical coherence tomography, TLR target lesion revascularisation, TVF target vessel failure, TVR target vessel revascularisation, PCI percutaneous coronary intervention, POBA plain old balloon angioplasty