Table-IV.
Relationship between IL-6-174G>C, -592G>C and -597G>A polymorphisms and development of coronary artery disease
| Variables | Patients n=275 | % | Controls n=296 | % | OR(95%CI)1 | P value |
|---|---|---|---|---|---|---|
| IL-6-174G>C | ||||||
| GG | 256 | 93.09 | 282 | 95.27 | 1.0 (Ref.) | - |
| GC | 19 | 6.91 | 14 | 4.73 | 1.49 (0.69-3.29) | 0.26 |
| CC | 0 | 0.00 | 0 | 0.00 | - | - |
| Allele | ||||||
| G | 531 | 96.55 | 578 | 97.64 | 1.0 (Ref.) | - |
| C | 19 | 3.46 | 14 | 2.37 | 1.48(0.69-3.22) | 0.27 |
| -592A>C | ||||||
| AA | 86 | 31.27 | 135 | 45.61 | 1.0 (Ref.) | - |
| AC | 134 | 48.73 | 129 | 43.58 | 1.63(1.12-2.38) | 0.01 |
| CC | 55 | 20.00 | 32 | 10.81 | 2.70(1.57-4.67) | <0.001 |
| Allele | ||||||
| A | 306 | 55.64 | 399 | 67.40 | 1.0 (Ref.) | - |
| C | 244 | 44.36 | 193 | 32.60 | 1.65(1.29-2.11) | <0.001 |
| -597G>A | ||||||
| GG | 263 | 95.64 | 274 | 92.57 | 1.0 (Ref.) | - |
| GA | 12 | 4.36 | 22 | 7.43 | 0.57(0.25-1.23) | 0.12 |
| AA | 0 | 0.00 | 0 | 0.00 | - | - |
| Allele | ||||||
| G | 538 | 97.82 | 570 | 96.28 | 1.0 (Ref.) | - |
| A | 12 | 2.18 | 22 | 3.72 | 0.58(0.26-1.23) | 0.13 |
1
Ajusted for age, gender, BMI, family history of coronary artery disease, hypertension, type 2 diabetes mellitus, TC, LDL-c and HDL-c. OR: odds ratio; CI: confidence interval.