Table 2. Marker expressions as predictor for BFFS, CFFS and PCDFS in PCa patients (n = 535), (univariate analysis; log rank test), significant p-values in bold (threshold p ≤ 0.05).
| |
Patients (n) | Patients (%) | BFFS |
CFFS |
PCDFS |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Marker expression | 5-year (%) | 10-year (%) | p | 5-year (%) | 10-year (%) | p | 5-year (%) | 10-year (%) | p | |||
| ERα TS | Low | 144 | 26.9 | 73 | 67 | 0.819 | 94 | 86 | 0.042 | 98 | 89 | 0.019 |
| High | 373 | 69.7 | 74 | 61 | 97 | 93 | 99 | 98 | ||||
| Missing | 18 | 3.4 | ||||||||||
| ERβ TS | Low | 368 | 68.8 | 77 | 66 | 0.002 | 97 | 91 | 0.658 | 100 | 97 | 0.486 |
| High | 149 | 27.9 | 67 | 54 | 95 | 91 | 99 | 97 | ||||
| Missing | 18 | 3.4 | ||||||||||
| Aromatase TS | Low | 131 | 24.5 | 66 | 54 | 0.016 | 94 | 90 | 0.225 | 98 | 91 | 0.668 |
| High | 386 | 72.1 | 77 | 65 | 97 | 91 | 99 | 98 | ||||
| Missing | 18 | 3.4 | ||||||||||
| Aromatase TE | Low | 275 | 51.4 | 73 | 61 | 0.487 | 95 | 93 | 0.036 | 98 | 96 | 0.061 |
| High | 242 | 45.2 | 75 | 64 | 97 | 96 | 99 | 97 | ||||
| Missing | 18 | 3.4 | ||||||||||
Abbreviations: ERα = estrogen receptor alpha; ERβ = estrogen receptor beta; TE = tumor epithelial cells; TS = tumor stromal cells; BFFS = Biochemical failure free survival; CFFS = clinical failure free survival; PCDFS = prostate cancer death free survival.