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. Author manuscript; available in PMC: 2017 Oct 1.
Published in final edited form as: Neuropharmacology. 2016 Jun 22;109:293–305. doi: 10.1016/j.neuropharm.2016.06.022

Figure 3.

Figure 3

Disruption of contextual fear memory reconsolidation by ketamine. In panel (A), the experimental timeline is depicted. The analysis of the percentage of time spent freezing (B) before (Pre) and 24 hrs after ketamine treatment (Post), reveals a reduction in freezing in rats treated with ketamine at the 10 mg/kg dose (i.p.), but not 20 mg/kg or saline. This translates into a positive extinction index (C) in 10 but not 20 mg/kg ketamine- or saline-treated animals. A linear regression analysis between Extinction Index in rats treated with 10 mg/kg and Locomotor score (D) revealed the absence of relationship between novelty seeking phenotype and response to ketamine. Each individual data point is depicted within each column. ***p < 0.001; #p < 0.05 vs an index of “0”. Data are represented as mean ± SEM.