Table 2. Top 12 most differentially abundant plasma metabolites (Bonferroni adjusted p < 0.01).
| Metabolite | ∆PH-∆Control | p-value | FDR |
|---|---|---|---|
| PC ae C36:4 | −0.340 | 1.97E-08 | 3.00E-06 |
| PC aa C40:4 | −0.263 | 4.00E-06 | 2.20E-04 |
| PC ae C38:4 | −0.246 | 4.00E-06 | 2.20E-04 |
| PC aa C40:6 | −0.278 | 7.00E-06 | 2.29E-04 |
| PC ae C36:5 | −0.265 | 8.00E-06 | 2.29E-04 |
| PC aa C38:3 | −0.262 | 2.00E-05 | 4.75E-04 |
| PC ae C38:6 | −0.254 | 2.20E-05 | 4.75E-04 |
| PC aa C40:5 | −0.261 | 3.60E-05 | 6.91E-04 |
| PC ae C38:5 | −0.204 | 4.50E-05 | 7.62E-04 |
| PC aa C38:4 | −0.205 | 5.00E-05 | 7.62E-04 |
| PC ae C36:0 | −0.211 | 5.80E-05 | 7.79E-04 |
| PC aa C38:0 | −0.215 | 6.10E-05 | 7.79E-04 |
Delta was calculated after log2 transformation of metabolite expression data (μM), computing the difference between post-treatment and baseline for each patient, and computing the average of that difference separately for PH and control groups.