Table IV.
Significant association between IL10 SNPs and helminth chronic infection, current infection, and coinfection for A lumbricoides and T trichiura by using logistic regression adjusted by sex and age
| Marker | Chromosome | Base pairs | Allele | MAF | No. | OR | CI | P value | EMP1 |
|---|---|---|---|---|---|---|---|---|---|
| A lumbricoides chronic infection | |||||||||
| rs3024492 | 1 | 206944112 | A | 0.07 | 772 | 0.37 | 0.15-0.95 | .038 | 0.029 |
| rs3024498 | 1 | 206941529 | C | 0.18 | 775 | 0.58 | 0.34-0.98 | .041 | 0.039 |
| T trichiura chronic infection | |||||||||
| rs3024498 | 1 | 206941529 | C | 0.18 | 840 | 0.25 | 0.11-0.54 | .0004 | 0.0003 |
| rs3024492 | 1 | 206944112 | A | 0.07 | 850 | 0.31 | 0.11-0.88 | .027 | 0.033 |
| T trichiura current infection | |||||||||
| rs3024498 | 1 | 206941529 | C | 0.18 | 1248 | 0.68 | 0.50-0.94 | .019 | 0.020 |
| rs3024505 | 1 | 206939904 | A | 0.09 | 1263 | 0.58 | 0.34-1.00 | .049 | 0.049 |
| Coinfection by A lumbricoides and T trichiura | |||||||||
| rs3024505 | 1 | 206939904 | A | 0.09 | 1263 | 0.63 | 0.41-0.95 | .023 | 0.029 |
| rs3024498 | 1 | 206941529 | C | 0.18 | 1248 | 0.77 | 0.59-0.99 | .047 | 0.059 |
| IgG4 anti–A lumbricoides | |||||||||
| rs3024498 | 1 | 206941529 | C | 0.18 | 1265 | 0.60 | 0.43-0.83 | .002 | 0.002 |
| IgE anti–A lumbricoides | |||||||||
| rs3024498 | 1 | 206941529 | C | 0.18 | 1268 | 0.76 | 0.61-0.93 | .009 | 0.011 |
Statistically significant values are shown in boldface. HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; OR, odds ratio.