Table V.
Significant association between IL10 SNPs and atopic asthma, total and specific IgE levels, and SPT responses by using logistic regression adjusted by sex, age, and helminth infection
| Marker | Chromosome | Base pairs | Allele | MAF | No. | OR | CI | P value | EMP1 |
|---|---|---|---|---|---|---|---|---|---|
| Atopic wheezing | |||||||||
| rs3024492 | 1 | 206944112 | A | 0.07 | 747 | 1.80 | 1.13-2.85 | .013 | 0.018 |
| SPT response to B germanica (≥3 mm) | |||||||||
| rs3024492 | 1 | 206944112 | A | 0.07 | 1258 | 1.99 | 1.23-3.25 | .005 | 0.004 |
| rs3024496 | 1 | 206941864 | G | 0.38 | 1261 | 1.31 | 0.98-1.74 | .067 | 0.045 |
| SPT response to P americana (≥3 mm) | |||||||||
| rs3024492 | 1 | 206944112 | A | 0.07 | 1258 | 1.73 | 1.15-2.59 | .008 | 0.007 |
| Specific IgE B germanica (>0.70 kU/L) | |||||||||
| rs1800872 | 1 | 206946407 | T | 0.38 | 1264 | 0.77 | 0.60-0.97 | .027 | 0.038 |
| Specific IgE D pteronyssinus (>0.70 kU/L) | |||||||||
| rs3024505 | 1 | 206939904 | A | 0.09 | 1263 | 1.53 | 1.07-2.19 | .020 | 0.018 |
Statistically significant values are shown in boldface. HWE, Hardy-Weinberg equilibrium; MAF, minor allele frequency; OR, odds ratio.