Table 1.
Characteristics of the 967 acute decompensated heart failure patients according to change in PVol tertiles.
| Change PVol tertiles |
|||||
|---|---|---|---|---|---|
| All | 1 <5.08% | 2 −5.00 to 7.37% | 3 >7.41% | ||
| n = 967 | n = 322 | n = 323 | n = 322 | p value | |
| Change in PVol (%) | 3.06 ± 17.22 | −13.8 ± 7.68 | 1.02 ± 3.57 | 22.0 ± 13.2 | <0.001 |
| Z change PVol | −0.08 ± 0.81 | −0.86 ± 0.36 | −0.17 ± 0.17 | 0.809 ± 0.616 | <0.001 |
| Demographics | |||||
| Age (years) | 74.3 ± 12.4 | 73.5 ± 12.5 | 74.6 ± 12.5 | 74.7 ± 12.2 | NS |
| Male (%) | 602 (62) | 207 (64) | 191 (59) | 204 (63) | NS |
| Admission SBP | 133 ± 27 | 133 ± 26.1 | 133 ± 26.5 | 133 ± 29.6 | NS |
| Previous history | |||||
| Heart failure | 344 (36) | 116 (36) | 110 (34) | 118 (37) | NS |
| Ischaemic heart disease | 309 (32) | 99 (31) | 96 (30) | 114 (35) | NS |
| Hypertension | 560 (58) | 183 (57) | 193 (60) | 184 (57) | NS |
| Diabetes mellitus | 315 (33) | 102 (32) | 118 (37) | 95 (30) | NS |
| NYHA class | |||||
| ≤2 | 56 (5.8) | 20 (6.2) | 20 (6.2) | 16 (5.0) | NS |
| 3 | 394 (41) | 145 (45) | 120 (37) | 129 (40) | NS |
| 4 | 502 (52) | 152 (47) | 177 (55) | 173 (54) | NS |
| ADHERE score | |||||
| 1 | 595 (62) | 196 (61) | 201 (62) | 198 (62) | NS |
| 2 | 164 (17) | 58 (18) | 51 (16) | 55 (17) | NS |
| 3 | 100 (10) | 30 (9.3) | 40 (12) | 30 (9.3) | NS |
| 4 | 52 (5.4) | 16 (5.0) | 15 (4.6) | 21 (6.5) | NS |
| 5 | 12 (1.2) | 7 (2.2) | 3 (0.9) | 2 (0.6) | NS |
| Admission blood tests | |||||
| Creatinine (µmol/L) | 127 ± 55.2 | 126 ± 57.3 | 124 ± 52.9 | 131 ± 55.2 | NS |
| Sodium (mmol/L) | 137 ± 5.4 | 137 ± 5.1 | 137 ± 6.0 | 137 ± 5.1 | NS |
| Urea (mmol/L) | 10.9 ± 6.6 | 10.8 ± 6.6 | 10.8 ± 6.9 | 11.0 ± 6.2 | NS |
| Hb (g/dL) | 123 ± 19.9 | 115 ± 19.6 | 123 ± 18.3 | 131 ± 18.6 | <0.001 |
| Hct (L/L) | 0.370 ± 0.060 | 0.352 ± 0.054 | 0.372 ± 0.053 | 0.396 ± 0.054 | <0.001 |
| Discharge blood tests | |||||
| Hb (g/dL) | 121 ± 19.3 | 126 ± 20.2 | 122 ± 18.3 | 116 ± 18.0 | <0.001 |
| Hct (L/L) | 0.370 ± 0.056 | 0.389 ± 0.056 | 0.371 ± 0.053 | 0.353 ± 0.054 | <0.001 |
| End points | |||||
| Time to death (days) | 769 ± 653 | 777 ± 639 | 829 ± 680 | 701 ± 633 | 0.043 |
| Time to death and/or HF hospitalisation (days) | 639 ± 635 | 664 ± 634 | 693 ± 663 | 561 ± 601 | 0.022 |
| Death | 536 (55) | 160 (50) | 175 (54) | 201 (62) | 0.004 |
| Death and/or HF hospitalisation | 626 (64.7) | 193 (60) | 207 (64) | 226 (70) | 0.024 |
Numerical data are presented as n (%). The numbers (%) or mean ± SD are reported. p values are quoted for the ANOVA or Chi-squared tests for continuous or categorical variables, respectively. ADHERE: Acute Decompensated Heart Failure National Registry; ADHF: acute decompensated heart failure; HF: heart failure; NYHA: New York Heart Association; PVol: plasma volume; SBP: systolic blood pressure.