Table 2.
Cox regression analysis for death.
| Univariable HR (95% CI) | p | Multivariable model 1 HR (95% CI) | p | Multivariable model 2 HR (95% CI) | p | |
|---|---|---|---|---|---|---|
| Age (years) | 1.046 (1.037–1.055) | 0.000 | 1.044 (1.034–1.055) | 0.000 | 1.044 (1.034–1.055) | 0.000 |
| Male sex | 0.974 (0.819–1.158) | NS | 1.050 (0.869–1.269) | NS | 1.061 (0.878–1.282) | NS |
| Admission creatinine (µmol/L) | 1.006 (1.005–1.008) | 0.000 | 1.000 (0.998–1.003) | NS | 1.000 (0.998–1.003) | NS |
| Admission urea (mmol/L) | 1.064 (1.052–1.076) | 0.000 | 1.039 (1.018–1.061) | 0.000 | 1.041 (1.020–1.063) | 0.000 |
| Admission sodium (mmol/L) | 0.980 (0.966–0.994) | 0.005 | 0.974 (0.959–0.989) | 0.000 | 0.972 (0.957–0.987) | 0.000 |
| Admission systolic BP (mmHg) | 0.993 (−.990–0.997) | 0.000 | 0.995 (0.991–0.998) | 0.005 | 0.995 (0.992–0.999) | 0.008 |
| Past history | ||||||
| Ischaemic heart disease | 1.362 (1.146–1.619) | 0.000 | 1.168 (0.971–1.404) | NS | 1.139 (0.946–1.371) | NS |
| Hypertension | 1.078 (0.907–1.281) | NS | 0.845 (0.699–1.021) | NS | 0.866 (0.716–1.047) | NS |
| HF | 1.561 (1.313–1.855) | 0.000 | 1.096 (0.908–1.323) | NS | 1.115 (0.923–1.347) | NS |
| Diabetes | 1.219 (1.021–1.456) | 0.029 | 1.245 (1.027–1.508) | 0.025 | 1.244 (1.027–1.507) | 0.026 |
| NYHA functional classification | ||||||
| ≤2 (Reference) | 1 | 1 | 1 | |||
| 3 | 3.500(1.955–6.264) | 0.000 | 2.598 (1.411–4.785) | 0.002 | 2.574 (1.398–4.740) | 0.002 |
| 4 | 4.989 (2.797–8.898) | 0.000 | 3.283 (1.783–6.043) | 0.000 | 3.225 (1.751–5.937) | 0.000 |
| Z change PVol | 1.151 (1.039–1.274) | 0.007 | Excluded | 1.150 (1.031–1.283) | 0.012 | |
Multivariable analysis results are reported for model 1 which included variables which were significant on univariable analysis. Multivariable model 2 used the variables in model 1 with the addition of change in PVol as a continuous variable. BP: blood pressure; CI: confidence interval; HF: heart failure; NYHA: New York Heart Association; PVol: plasma volume.