Table 3.

Cox regression analysis for death or HF hospitalisation.

	Univariable HR (95% CI)	p	Multivariable model 1 HR (95% CI)	p	Multivariable model 2 HR (95% CI)	p
Age (years)	1.031 (1.023–1.038)	0.000	1.027 (1.018–1.035)	0.000	1.027 (1.018–1.035)	0.000
Male sex	1.003 (0.854–1.179)	NS	1.008 (0.846–1.202)	NS	1.017 (0.853–1.212)	NS
Admission creatinine (µmol/L)	1.005 (1.004–1.006)	0.000	1.000 (0.998–1.002)	NS	1.000 (0.997–1.002)	NS
Admission urea (mmol/L)	1.051 (1.040–1.063)	0.000	1.030 (1.010–1.050)	0.003	1.032 (1.012–1.052))	0.002
Admission sodium (mmol/L)	0.986 (0.972–0.999)	0.033	0.985 (0.971–0.999)	0.034	0.984 (0.970–0.998)	0.025
Admission systolic BP (mmHg)	0.994 (0.991–0.997)	0.000	0.996 (0.993–0.999)	0.012	0.996 (0.993–0.999)	0.015
Past history
HF	1.647 (1.404–1.932)	0.000	1.217 (1.021–1.450)	0.028	1.230 (1.032–1.466)	0.021
Ischaemic heart disease	1.446 (1.232–1.697)	0.000	1.244 (1.049–1.476)	0.012	1.215 (1.023–1.443)	0.026
Hypertension	1.145 (0.975–1.344)	NS	0.922 (0.775–1.097)	NS	0.941 (0.790–1.121)	NS
Diabetes	1.368 (1.161–1.611)	0.000	1.346 (1.129–1.605)	0.001	1.343 (1.126–1.601)	0.001
NYHA functional classification
≤2 (Reference)	1		1		1
3	2.368 (1.516–3.700)	0.000	1.816 (1.145–2.881)	0.011	1.824 (1.150–2.894)	0.011
4	3.263 (2.096–5.080)	0.000	2.245 (1.414–3.564)	0.001	2.234 (1.407–3.547)	0.001
Z change PVol	1.139 (1.036–1.252)	0.007	Excluded		1.138 (1.029–1.259)	0.012

Multivariable analysis results are reported for model 1 which included variables which were significant on univariable analysis. Multivariable model 2 used the variables in model 1 with the addition of change in PVol as a continuous variable. BP: blood pressure; CI: confidence interval; HF: heart failure; NYHA: New York Heart Association; PVol: plasma volume.