Fig 3. Significant pathways affected by differential gene expression at embryonic stages and D35.

Up (U) or Down (D) regulation of DEG associated with each comparison (versus control) are separated within each thermal modification: increase (H) or decrease (L) in incubation temperature during ED7-10 (H10 and L10) or ED10-13 (H13 and L13). Significant pathways are grouped into eight major categories (sc.): sc.1 cell maintenance, proliferation, differentiation, and replacement; sc.2 organismal organ and tissue development; sc.3 nutrient metabolism; sc.4 genetic information and nucleic acid processing; sc.5 molecular transport; sc.6 cell signaling and interaction; sc.7 small molecule biochemistry; and sc.8 response to stimuli and associated. The—log (p values) related with significant pathways (Benjamini Hochberg corrected) are plotted in green (small) to red (large).