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. 2016 Sep 9;11(9):e0162638. doi: 10.1371/journal.pone.0162638

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© 2016 Chen et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 5 — (A) The BCP-ALL in data set GSE11877, including 207 high-risk patient samples, were classified into four clusters according the expression levels of IGHM, IGLL1 and VPREB1: IGHM+IGLL1+VPREB1+ (Cluster 1), IGHM+IGLL1+/-VPREB1+/- (not including IGHM+IGLL1+VPREB1+) (Cluster 2), IGHM-IGLL1+/-VPREB1+/- (not including IGHM-IGLL1-VPREB1-) (Cluster 3) and IGHM-IGLL1-VPREB1- (Cluster 4). (B) Genes highly expressed in pre-B cells are enriched in Cluster 1. Left: The pre-B signature was identified using supervised comparison in data set GSE45460. Middle: Heat map of the pre-B signature in Cluster 1 and the remaining ALL. Right: Enrichment plot shows the enrichment of pre-B signature in the Cluster 1. (C) Genes highly expressed in Cluster 1 are enriched in pre-B cells. Left: The top 400 genes highly expressed in Cluster 1 (Cluster 1 signature) were identified using supervised comparison. Middle: Heat map of the Cluster 1 signature in healthy pre-B cells. Right: Enrichment plot shows the enrichment of Cluster 1 signature in healthy pre-B cells. (D) Pie-chart shows the distribution of genetic subtypes in clusters 1–4. (E) Genes highly expressed in pre-B cells are enriched in the TCF3-PBX1 ALL from Cluster 1 but not that from other clusters. Left: Heat map of the pre-B signature in the TCF3-PBX1 ALL from Cluster1. Right: Enrichment plot shows the enrichment of pre-B signature in the TCF3-PBX1 ALL from Cluster 1. (F) Genes highly expressed in pre-B cells are enriched in Cluster 1 without TCF3-PBX1. Left: Heat map of the pre-B signature in the Cluster1 without TCF3-PBX1. Right: Enrichment plot shows the enrichment of pre-B signature in Cluster 1 without the TCF3-PBX1 ALL.