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. 2016 Sep 9;11(9):e0162633. doi: 10.1371/journal.pone.0162633

Fig 3. Cdc6 depletion inhibits PTX-induced mitotic slippage and reverses PTX resistance.

Fig 3

(A) HepG2 cells were treated with combination with or without Cdc6 RNAi or NCTD (30 μM) as described in Fig 2. At day 7, Cells were stained with Giemsa dye and the percentage of slippage cells is presented (right panel). (B) Cell cycle was analyzed by FACS. G2/M (upper) and G1 (below) percentage were presented in right panel. (C) Cell viability after PTX treatment combined with or without NCTD (30 μM) for 10 days was valued by typan blue assay. All of the experiments were performed in three independent experiments, *P<0.05 as compared to PTX group.