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Once HU 308 binds to CB2R receptor in macrophages, phosphorylates the AMPK-mTOR-P70S6K signaling cascades and thus promotes peritoneal macrophages autophagy. Augment of autophagy inhibits NLRP3 inflammasome initiation and activation, which decreases Casp-1 activation and IL-1β mature and alleviates an inflammatory cascade.
