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. 2016 Sep 9;11(9):e0162182. doi: 10.1371/journal.pone.0162182

Table 3. Factors associated with increased vertical-horizontal ALID difference.

Variable Univariate analysis Multivariable analysis 1* Multivariable analysis 2*
Beta Standard error P-value Beta Standard error P-value Beta Standard error P-value
Age, for each year older 1.166 0.344 0.001 0.878 0.361 0.016 0.614 0.369 0.10
Gender, male –14.568 8.476 0.09 –4.917 8.568 0.57 –8.468 8.779 0.34
DM 31.535 14.76 0.035 26.210 13.781 0.06 27.733 14.358 0.06
HTN 15.640 9.314 0.11
Diagnosis < 0.001 <0.001
HTG 7.197 10.546 0.33 11.402 14.776 0.44
NTG 47.299 9.000 < 0.001 44.265 11.338 <0.001
Healthy Ref Ref
Baseline IOP, per 1 mmHg increase –1.741 0.771 0.025 –2.835 1.030 0.007
IOP at examination, per 1 mmHg increase –2.686 1.502 0.08 1.190 1.732 0.49
AXL, per 1 mm increase –1.843 3.378 0.56
CCT, per 1 μm increase –0.249 0.133 0.09 –0.049 0.133 0.71 –0.025 0.139 0.86
MD of VF, per 1 dB increase –0.858 2.066 0.41
Average RNFLT, per 1 μm increase –0.809 0.299 0.031 –0.140 0.420 0.74 –1.260 0.345 <0.001

Statistical analysis was performed using the general linear model. Statistically significant values are shown in bold,

* Factors with P < 0.10 in the univariate analysis were included in the multivariable analysis.

DM = diabetes mellitus; HTN = hypertension; HTG = high-tension glaucoma; NTG = normal-tension glaucoma; IOP = intraocular pressure; AXL = axial length; CCT = central corneal thickness; MD = mean deviation; VF = visual field; RNFLT = retinal nerve fiber layer thickness