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. 2016 Sep 9;11(9):e0161883. doi: 10.1371/journal.pone.0161883

Fig 9. Effects of chronic Theiler’s murine encephalomyelitis virus (TMEV)-infection (experiment II) on cytokine expression and phenotypical changes in spleens of interleukin-10 receptor (IL-10R) neutralized SJL mice.

Fig 9

(A-H) Significantly elevated mRNA levels of IL-1α, IL-2, IL-4, IL-6, TNF, IFN-γ, TGF-β and IL-10 in spleens of infected mice (group “IL-10R↓late/TMEV”) compared to non-infected animals following IL-10R antibody (Ab) treatment (group “IL-10R↓late/mock”). (I) Flow cytometry revealed a relative increase of CD8+ cells in the spleens of TMEV-infected mice with IL-10R Ab treatment at 49 dpi. For gating strategy see S2 Fig. IL-10R Ab treated mice without TMEV-infection (group “IL-10R↓late/mock”). IL-10R Ab treated mice with TMEV-infection (group “IL-10R↓late/TMEV”). Box and whisker plots display median, minimum and maximum values as well as upper and lower quartiles, 5 animals used in both groups, Wilcoxon rank-sum tests, *  =  p < 0.05.