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. 2016 Sep 9;11(9):e0160096. doi: 10.1371/journal.pone.0160096

Fig 3. Ingenol mebutate 0.05% gel activates cutaneous blood vessels and induces epidermal cell death.

Fig 3

Biopsy specimens from both treatment areas of all patients (n = 26) and all time points were assessed immunohistochemically for expression of CD20+ B-lymphocytes, ICAM-1 (CD54), and CD1a+ cells. Cleaved caspase 3 and TdT-mediated dUTP-biotin nick end labeling (TUNEL) reactivity indicating apoptotic responses were detected in five of these patients (arrows indicate examples of TUNEL positive epidermal cells). The figure depicts representative slides from all stainings as indicated. The scale bar represents 100 μm.