Table 1. Demographic and clinical characteristics of drug-resistant tuberculosis patients on Linezolid-containing regimen in Mumbai, India, January 2013-April 2016.
| Explanatory Variable | DR-TB patients on Lzd-containing regimen (N = 86), n(%) | Patients with presumptive optic neuropathy┼ (N = 24), n(%) | Patients without presumptive optic neuropathy┼(N = 62), n (%) | Chi-square/ t-test (p-value) |
|---|---|---|---|---|
| Age [years, mean (SD)] | 27.5 (9.9) | 29.1 (10.1) | 26.9 (9.9) | 0.94 (0.35) |
| Sex of patients | ||||
| Male | 40 (46.5) | 13 (32.5) | 27 (67.5) | 0.78 (0.38) |
| Female | 46 (53.5) | 11 (23.9) | 35 (76.1) | |
| HIV co-infection | 17 (19.8) | 6 (35.3) | 11 (64.7) | 0.58 (0.45) |
| TB site | ||||
| Pulmonary | 80 (93.0) | 22 (27.5) | 58 (72.5) | 0.2 (1.0) |
| Extra-pulmonary | 6 (7.0) | 2 (33.3) | 4 (66.7) | |
| DR-TB resistance pattern | ||||
| PDR or MDR | 7 (8.1) | 3 (42.9) | 4 (57.1) | 6.1 (<0.05) |
| Pre-XDR | 36 (41.9) | 5 (13.9) | 31 (86.1) | |
| XDR and above | 43 (50.0) | 16 (37.2) | 27 (62.8) |
┼Row percentage in parenthesis; Lzd: linezolid; SD: Standard deviation; PDR: Poly-drug resistant; MDR: Multi-drug resistant; Pre-XDR: Pre-extensively-drug resistant; XDR: Extensively drug resistant