Table 2. Demographic and clinical characteristics of drug-resistant tuberculosis patients with linezolid-associated optic neuropathy, Mumbai, January 2013-April 2016.
| Case | Sex /Age | TB site | DR-TB pattern | Clinical symptoms/ signs | Ophthalmological Evaluation (in either eye) | Treatment regimen | LZD(m) |
|---|---|---|---|---|---|---|---|
| 1 | F/22 | PTB | XDR | - B/L blurring of vision, -S/S of Peripheral neuropathy | -VA: 6/60, NV<N36, -OM & ASE with slit lamp: N, DLE: B/L hyperemic, mildly elevated optic nerve heads, -R&V: N | Capreomycin inj 750 mg OD, levofloxacin 750 mg OD, cycloserine 500 mg OD, Para-amino-salicylate 9gm/day, amoxicilline-clavulanate 625mg TDS, clofazimine 100mg OD, linezolid 600 mg OD), bedaquilline | 11 |
| 2 | F/22 | PTB | XDR | - B/L blurring of vision-S/S of Peripheral neuropathy | -VA: 6/24, NV<N36, -OM & ASE with slit lamp: N, -DLE: B/L mildly hyperemic, elevated optic nerve heads-R&V: N | Capreomycin 1g OD, Ethambutol 800 mg/day levofloxacin 1000 mg OD, cycloserine 500 mg OD, Para-amino-salicylate PAS, 9.2 gm/day, clofazimine 100 mg OD, amoxycilin-clavulanic acid 625mg TDS, linezolid 600 mg OD | 11 |
| 3 | M/25 | PTB | MDR | - B/L blurring of vision | -VA: 6/60, NV<N36-OM & ASE with slit lamp: N-DLE: B/L mildly hyperemic, elevated optic nerve heads-R&V: N | levofloxacin 1000 mg OD, cycloserine 500 mg OD, Para-amino-salicylate 9.2 gm/day, clofazimine 100 mg OD, amoxycilin-clavulanic acid 1000 mg/250 mg/ day, linezolid 600 mg OD | 10 |
| 4 | F/29 | PTB | XXDR | - B/L blurring of vision | -VA: 6/45 (R), 6/30 (L), NV<N36-OM & ASE with slit lamp: N-DLE: B/L mildly hyperemic, elevated optic nerve heads-R&V: N | Capreomycin inj 750 mg OD, clofazimine 100 mg OD, amoxycilin-clavulanic acid 1000 mg/250 mg/ day, linezolid 600 mg OD | 7 |
| 5 | M/32 | PTB | XXDR | - B/L blurring of vision | -VA: 6/60, NV<N36-OM & ASE with slit lamp: N-DLE: B/L mildly hyperemic, elevated optic nerve heads-R&V: N | Capreomycin inj 1000 mg OD, ethionamide 750 mg OD, clofazimine 100 mg OD, linezolid 600 mg OD, Delamanid 100mg BD, Imipenem 1g BD, Amoxi-Clav 625mg TDS | 11 |
F: Female; M: Male; PTB: Pulmonary TB; DR-TB: Drug resistant TB; XDR: Extensively drug-resistant; MDR: Multi drug-resistant; XXDR: Extremely drug-resistant; B/L: Bilateral; S/S: Symptoms & Signs; VA: Visual acuity; R: right; L: left; NV: near vision; OM & ASE: ocular motility and anterior segment evaluation; DLE: Dilated fundus examination; R &V: retina & vasculature; OD: once daily; Lzd (m): Duration of Linezolid administration in months