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. 2016 Sep 9;11(9):e0161710. doi: 10.1371/journal.pone.0161710

Table 4. Mortality rate, hospitalizations and HRQoL for patients with COPD exacerbation based on the clusters at baseline (1 year period) and based on the clusters transition for a 1 year period.

Baseline First year 1 year later Second year
Cluster HRQoL* Mortality Hospitalizations Cluster HRQoL* Mortality Hospitalizations
n (%) n (%) n (%) n (%)
A (n = 164) 29.2 B,C,D (26.7–31.8) 2 (1.2) 16 (9.8) A (n = 116) 28.0 (24.4–31.5)C 0 (--) 6 (5.2)
B (n = 34) 28.9 (23.6–34.3) 0 (--) 3 (8.9)
C (n = 6) 47.4 (27.6–67.2)A 1 (16.7) 1 (16.7)
D (n = 1) (--) (--) (--)
P¥ 0.05£ 0.045 0.295
B (n = 195) 40.0 A,C (37.4–42.7) 8 (4.1) 35 (17.9) A (n = 7) 29.7 (12.4–47.1)C 0 (--) 1 (2.4)
B (n = 140) 36.7 (33.8–39.6)C 5 (3.6) 18 (12.9)
C (n = 29) 48.4 (41.4–55.4)A,B 7 (24.1) 11 (37.9)
D (n = 1) (--) (--) (--)
P¥ 0.003£ 0.003 0.012
C (N = 89) 55.1 A,B,D (51.2–59.1) 11 (12.4) 33 (37.1) A (n = 3) 66.9 (22.2–111.6) 0 (--) 0 (--)
B (n = 26) 50.1 (41.4–58.9) 0 (--) 8 (30.8)
C (n = 41) 53.0 (46.7–59.3) 7 (17.1) 18 (43.9)
D (n = 1) (--) (--) (--)
P¥ 0.406£ 0.117 0.356
D (n = 95) 39.6 A,C (35.7–43.5) 16 (16.8) 35 (36.8) A (n = 0) (--) (--) (--)
B (n = 16) 32.6 (23.7–41.5) 0 (--) 4 (25.0)
C (n = 10) 52.0 (36.2–67.9) 4 (40.0) 6 (60.0)
D (n = 49) 36.5 (30.7–42.3) 7 (14.3) 10 (20.4)
P¥ 0.05 0.021 0.039
P¥ <0.001 <0.001 <0.001

* HRQoL is measured with the total dimension score of the St. George´s Respiratory Questionnaire

¥ Chi-square test for mortality and hospitalizations and ANOVA for HRQoL are shown. Statistically significant differences between clusters are indicated with the corresponding superscript

£ Cluster D is excluded from the pairwise comparisons.

Results of groups with only one individual were not included.