Table 4. Age specific health care-seeking in the two years prior to vaccination in 316 Danish females who reported suspected adverse events to HPV vaccination compared with 163,910 matched controls.

Care-seeking was defined as contact to primary health care (from registry of reimbursements) or hospital (from the Danish National Patient Registry) in a two-year period before the first HPV vaccine. The analyses were restricted to significant variables from the final multivariable model, see Table 3.

		Cases		Controls
Type of contact before first vaccination	Age at first HPV vaccine	Number	Percent	Number	Percent	Odds ratio*	95% CI	p-value for interaction with age**
Consultation at primary health care provider by phone or e-mail	10–12 years	78	86.7	39739	77.0	2.11	1.25–3.59	0.567
	13–18 years	51	94.4	23176	79.4	1.23	0.81–1.87
	19–28 years	118	98.3	77003	96.1	1.92	1.28–2.90
	29 years +	52	100.0	2944	99.2	23.54	15.21–36.46
Reimbursement of physiotherapy, chiropractor or related treatment	10–12 years	12	13.3	3032	5.9	1.91	1.05–3.44	0.104
	13–18 years	14	25.9	2700	9.2	1.62	0.73–3.61
	19–28 years	49	40.8	13809	17.2	1.58	0.82–3.07
	29 years +	21	40.4	918	30.9	9.95	4.73–20.93
Reimbursement of psychologist, psychiatrist or related treatment	10–12 years	3	3.3	520	1.0	2.54	0.81–7.97	0.486
	13–18 years	2	3.7	494	1.7	0.88	0.15–5.36
	19–28 years	27	22.5	8409	10.5	0.87	0.26–2.93
	29 years +	7	13.5	328	11.1	5.80	1.46–22.99
ICD 10 code K00-K93, the digestive system	10–12 years	2	2.2	909	1.8	0.93	0.23–3.76	0.782
	13–18 years	2	3.7	652	2.2	1.71	0.24–12.27
	19–28 years	14	11.7	3726	4.7	2.48	0.56–11.06
	29 years +	5	9.6	133	4.5	23.32	4.41–123.31
ICD 10 code M00-M99, the musculoskeletal system and connective tissue	10–12 years	4	4.4	1575	3.1	1.13	0.42–3.05	0.629
	13–18 years	4	7.4	1306	4.5	1.51	0.37–6.12
	19–28 years	23	19.2	5409	6.8	2.48	0.85–7.30
	29 years +	7	13.5	226	7.6	17.97	5.12–63.06
ICD 10 code R00-R99, symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified	10–12 years	9	10.0	2052	4.0	1.95	1.00–3.81	0.465
	13–18 years	7	13.0	1220	4.2	1.62	0.59–4.42
	19–28 years	21	17.5	6210	7.8	1.07	0.48–2.39
	29 years +	7	13.5	227	7.7	9.77	3.54–26.99
ICD 10 code S00-T14, injuries	10–12 years	38	42.2	13945	27.0	1.25	0.87–1.79	0.681
	13–18 years	24	44.4	7352	25.2	1.53	0.89–2.64
	19–28 years	30	25.0	14028	17.5	1.14	0.68–1.91
	29 years +	10	19.2	368	15.6	3.95	7.42–32.59

Note: Cases/controls included: 10–12 years: 90/51,583; 13–18 years: 54/29,205; 19–28 years: 120/80,154; 29 years +: 52/2,968.

* Odds ratio from a logistic regression model adjusting for year of vaccination and province.

** Log-likelihood ratio test comparing main effects model with a model including main effects and an interaction term between age group and care-seeking