Table 4. Potential cellular biological events predicted from the microRNA target genes.
| miRNA | Category | Term | Fold enrichment1 | Benjamini |
|---|---|---|---|---|
| miR-10b | ||||
| GOTERM_BP_FAT | GO:0007156~homophilic cell adhesion | 4.535 | 0.003 | |
| GOTERM_BP_FAT | GO:0016337~cell-cell adhesion | 3.443 | 0.004 | |
| GOTERM_BP_FAT | GO:0022610~biological adhesion | 2.203 | 0.062 | |
| GOTERM_BP_FAT | GO:0007155~cell adhesion | 2.203 | 0.062 | |
| miR-17-5p | ||||
| GOTERM_BP_FAT | GO:0006468~protein amino acid phosphorylation | 2.161 | 0.010 | |
| GOTERM_BP_FAT | GO:0045449~regulation of transcription | 1.598 | 0.017 | |
| GOTERM_BP_FAT | GO:0006796~phosphate metabolic process | 1.836 | 0.021 | |
| GOTERM_BP_FAT | GO:0006793~phosphorus metabolic process | 1.836 | 0.021 | |
| GOTERM_BP_FAT | GO:0016310~phosphorylation | 1.905 | 0.035 | |
| GOTERM_BP_FAT | GO:0010604~positive regulation of macromolecule metabolic process | 2.142 | 0.084 | |
| GOTERM_BP_FAT | GO:0007242~intracellular signaling cascade | 1.847 | 0.097 | |
| KEGG_PATHWAY | bta05219:Bladder cancer | 5.341 | 0.075 | |
| miR-19a | ||||
| GOTERM_BP_FAT | GO:0007242~intracellular signaling cascade | 2.012 | 0.028 | |
| GOTERM_BP_FAT | GO:0051094~positive regulation of developmental process | 3.299 | 0.075 | |
| KEGG_PATHWAY | bta04630:Jak-STAT signaling pathway | 2.985 | 0.012 | |
| KEGG_PATHWAY | bta05211:Renal cell carcinoma | 3.817 | 0.033 | |
| KEGG_PATHWAY | bta04930:Type II diabetes mellitus | 4.297 | 0.049 | |
| KEGG_PATHWAY | bta04144:Endocytosis | 2.268 | 0.058 | |
| KEGG_PATHWAY | bta04010:MAPK signaling pathway | 2.019 | 0.066 | |
| KEGG_PATHWAY | bta04150:mTOR signaling pathway | 3.981 | 0.071 | |
| KEGG_PATHWAY | bta05410:Hypertrophic cardiomyopathy (HCM) | 3.133 | 0.079 | |
| miR-29b | ||||
| KEGG_PATHWAY | bta04510:Focal adhesion | 3.529 | 0.000 | |
| KEGG_PATHWAY | bta04512:ECM-receptor interaction | 4.611 | 0.001 | |
| KEGG_PATHWAY | bta05200:Pathways in cancer | 2.201 | 0.008 | |
| KEGG_PATHWAY | bta05222:Small cell lung cancer | 3.705 | 0.011 | |
| KEGG_PATHWAY | bta04920:Adipocytokine signaling pathway | 3.529 | 0.097 | |
| miR-30b-5p | ||||
| GOTERM_BP_FAT | GO:0007242~intracellular signaling cascade | 1.996 | 0.034 | |
| GOTERM_BP_FAT | GO:0007519~skeletal muscle tissue development | 5.780 | 0.098 | |
| GOTERM_BP_FAT | GO:0060538~skeletal muscle organ development | 5.780 | 0.098 | |
| miR-98 | ||||
| KEGG_PATHWAY | bta04010:MAPK signaling pathway | 2.598 | < 0.001 | |
| KEGG_PATHWAY | bta05200:Pathways in cancer | 2.203 | 0.005 | |
| miR-142-5p | ||||
| KEGG_PATHWAY | bta05200:Pathways in cancer | 2.106 | 0.048 | |
| miR-301a | ||||
| GOTERM_BP_FAT | GO:0007242~intracellular signaling cascade | 2.211 | 0.001 | |
| GOTERM_BP_FAT | GO:0048514~blood vessel morphogenesis | 3.627 | 0.051 | |
| GOTERM_BP_FAT | GO:0044087~regulation of cellular component biogenesis | 4.885 | 0.073 | |
| GOTERM_BP_FAT | GO:0007264~small GTPase mediated signal transduction | 2.675 | 0.074 | |
| GOTERM_BP_FAT | GO:0008104~protein localization | 1.932 | 0.076 | |
| GOTERM_BP_FAT | GO:0009792~embryonic development ending in birth or egg hatching | 2.643 | 0.079 | |
| GOTERM_BP_FAT | GO:0043009~chordate embryonic development | 2.660 | 0.081 | |
| GOTERM_BP_FAT | GO:0001568~blood vessel development | 3.043 | 0.085 | |
| GOTERM_BP_FAT | GO:0051173~positive regulation of nitrogen compound metabolic process | 2.333 | 0.085 | |
| GOTERM_BP_FAT | GO:0001944~vasculature development | 3.165 | 0.086 | |
| GOTERM_BP_FAT | GO:0045935~positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process | 2.300 | 0.091 | |
| GOTERM_BP_FAT | GO:0010628~positive regulation of gene expression | 2.338 | 0.094 | |
| KEGG_PATHWAY | bta04144:Endocytosis | 2.784 | 0.003 | |
| KEGG_PATHWAY | bta04115:p53 signaling pathway | 4.262 | 0.006 | |
| KEGG_PATHWAY | bta04810:Regulation of actin cytoskeleton | 2.281 | 0.048 | |
| miR-2478 | ||||
| GOTERM_BP_FAT | GO:0045184~establishment of protein localization | 2.096 | 0.055 | |
| GOTERM_BP_FAT | GO:0015031~protein transport | 2.101 | 0.079 | |
| GOTERM_BP_FAT | GO:0008104~protein localization | 2.077 | 0.088 | |
| KEGG_PATHWAY | bta04340:Hedgehog signaling pathway | 4.629 | 0.079 | |
The data were statistically analyzed by DAVID as described in Materials and Methods.
1Fold enrichment = (genes in list that are annotated with the term)/(total numbers of genes that are annotated with any term in the term category)