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. 2016 Sep 9;11(9):e0162839. doi: 10.1371/journal.pone.0162839

Fig 4. Gene clustering of leptin receptor-expressing cholinergic neurons in the ARC.

Fig 4

A. Heatmap showing gene clustering in leptin receptor-positive cholinergic neurons. Genes were not randomly distributed across cells. For instance, the Chat gene clustered with peptide processing enzymes, including Cpe, Pcsk2, and Pam transcripts and the Lepr gene clustered with the PLCγ isoform (G1 gene group (G1)). The Th gene clustered with Gad1, Gad2, and Npy1r genes in the G2 gene group (G2). And Pomc, Pcsk1, and Nat1 did not cluster together (G3 gene group (G3)).