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. 2016 Sep 9;11(9):e0162658. doi: 10.1371/journal.pone.0162658

Fig 6. TGF-β1-induced glutaminolysis accelerates endothelial migration and PP2A-Raf-MEK-ERK pathway is involved in this process.

Fig 6

The cells were pretreated with U0126 (10μM) and OA (10 nM) for 30 minutes before TGF-β1 (10 ng/ml) stimulation and then cultured for 48 hours. (a) Cell migration was promoted by TGF-β1, and inhibition of PP2A-Raf-MEK-ERK pathway inhibited cells sprouting. (b) Bar graphs present the gap distance calculated by Image Pro Plus Software.**P<0.01 versus the control group, and *P<0.05 versus the TGF-β1 group. Bars represented means ±SEM.