Table 1. Baseline clinical variables of IgAN patients and analysis of those indicators affect ESRD by univariate Cox regression.
| Baseline variables | Total | Hazard Ratio (95% CI) | P value |
|---|---|---|---|
| (N = 930) | |||
| Age at biopsy, years | 37.57±11.83 | 1.01(0.99–1.02) | 0.55 |
| Female gender, n (%) | 472/930 (50.75%) | 0.55(0.37–0.80) | 0.002 |
| Body mass index, kg/m2 | 23.24±3.63 | 0.96(0.91–1.02) | 0.18 |
| Urine protein, g/24 h | 1.17(0.02–10.83) | 1.27(1.17–1.37) | <0.001 |
| Systolic blood pressure, mmHg | 128.22±17.35 | 1.02(1.01–1.03) | <0.001 |
| Diastolic blood pressure, mmHg | 80.92±12.10 | 1.03(1.02–1.04) | <0.001 |
| eGFR, ml/min/1.73m2 | 72.84±32.81 | 0.94(0.93–0.96) | <0.001 |
| Serum albumin, g/L | 34.76±6.67 | 0.95(0.92–0.97) | <0.001 |
| Hemoglobin, g/L | 128.16±20.22 | 0.98(0.97–0.98) | <0.001 |
| Urine Acid, μmol/l | 385.15±104.91 | 1.007(1.005–1.008) | <0.001 |
| Lymphocyte count, ×109/L | 2.31±0.78 | 0.63(0.47–0.86) | 0.003 |
| Serum cholesterol, mmol/L | 5.36±1.70 | 1.07(0.96–1.19) | 0.24 |
| Serum triglycerides, mmol/L | 1.89(0.45–11.68) | 1.08(0.96–1.22) | 0.2 |
| Serum C3, mg/dL | 104.26±26.54 | 0.99(0.98–0.999) | 0.03 |
| Renal deposition of C3, n (%) | 499/645 (77.36%) | 0.84(0.46–1.52) | 0.57 |
| C3 hypocomplementemia, n (%) | 181/728 (24.86%) | 1.33(0.84–2.10) | 0.22 |
| White blood cell, ×109/L | 7.55±2.22 | 0.95(0.86–1.05) | 0.33 |
| High sensitive C reactive protein, mg/L | 0.65(0.02–123.82) | 1.01(0.98–1.03) | 0.58 |
Abbreviations: C3: complement component 3; eGFR: estimated glomerular filtration rate. According to their normality, continuous data were expressed as mean ± standard deviation (SD) or median (range). Categorical data were expressed as percentages (%). univariate Cox regression was used to evaluate the association of baseline variables with the deterioration to ESRD.