Table 3. Intrinsic Clearance in Liver Microsomes.

	FTY720-C2	FTY720-Mitoxy
Species	Clint (μL/min/mg)a	Clint (μL/min/mg)a
Mouse	22.5 ± 2.12	1.75 ± 1.34
Rat	79.5 ± 1.41	7.8 ± 1.98
Dog	6.0 ± 0.28	1.35 ± 1.48
Monkey	20.2 ± 0	135.3 ± 10.61
Human	18.3 ± 2.4	17.5 ± 1.70

Cl_int—Intrinsic clearance.

^aValues represent the mean ± SD of two determinations.