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. 2016 Sep 9;2(9):e1601017. doi: 10.1126/sciadv.1601017

Fig. 1. Polymyxins and quinazolines bind LSD1-CoREST.

Fig. 1

(A) Chemical structures of polymyxin B and polymyxin E (colistin). Highlighted in blue are the positively charged propanamine units. Both antibiotics bind LSD1-CoREST with high affinity, as observed by inhibition and binding assays. (B) Chemical structures of quinazoline-derived compounds binding to LSD1. The atom numbering of the quinazoline core ring is shown for compound E11 as a reference for the compound series. Fluorescence polarization (FP) signal was measured in millipolarization units (mP) and plotted against inhibitor concentration. n.d., not determined.