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. 2016 Sep 9;2(9):e1501228. doi: 10.1126/sciadv.1501228

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Copyright © 2016, The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license, which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.

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Fig. 10 — The integrative models of the KCNE3-KCNQ1 complex are useful to visualize the S4 functional determinants of KCNE3 modulation in KCNQ1. The upper left panel highlights His²⁴⁰, Val²⁴¹, and Gln²⁴⁴ in cyan that are key to KCNE3 modulation. The upper right panel shows the same residues, zoomed in, with both a cartoon and transparent surface representation of the same region of KCNQ1. A surface representation (lower left) of these KCNQ1 residues (cyan) shows that these residues are surface-accessible in the KCNE3 binding cleft. The lower right panel shows the predicted hydrogen bond between KCNE3 Arg⁸³ and KCNQ1 Gln²⁴⁴, which suggest a potential mechanism for the distinct KCNE3 modulation of KCNQ1 and KCNQ4.