TABLE 1.
Lipid | Males
|
Females
|
||||
---|---|---|---|---|---|---|
Scd1+/+Ldlr−/− | Scd1−/−Ldlr−/− | P | Scd1+/+Ldlr−/− | Scd1−/−Ldlr−/− | P | |
Triglyceride, mg/dl | 885 ± 673 (11) | 497 ± 294 (8) | 0.23 | 689 ± 414 (12) | 350 ± 114 (9) | 0.021 |
Cholesterol, mg/dl | 2,192 ± 635 (11) | 1,614 ± 307 (8) | 0.023 | 1,927 ± 611 (12) | 1,769 ± 269 (9) | 0.86 |
HDL-cholesterol, mg/dl | 58.5 ± 14.5 (11) | 64.4 ± 8.3 (7) | 0.34 | 41.7 ± 12.2 (12) | 44.0 ± 10.9 (9) | 0.66 |
Non-HDL-cholesterol, mg/dl | 2,133 ± 627 (11) | 1,555 ± 306 (8) | 0.028 | 1,885 ± 612 (12) | 1,725 ± 268 (9) | 0.86 |
ApoB | 1.00 ± 0.60 (6) | 0.66 ± 0.15 (6) | 0.18 | 1.35 ± 0.42 (6) | 0.41 ± 0.15 (6) | 0.0022 |
ApoE | 1.00 ± 0.50 (6) | 0.75 ± 0.18 (6) | 0.24 | 1.29 ± 0.41 (6) | 0.45 ± 0.14 (6) | 0.0022 |
ApoC-III | 1.00 ± 0.37 (11) | 0.77 ± 0.26 (7) | 0.17 | 0.97 ± 0.31 (12) | 0.53 ± 0.15 (10) | 0.0005 |
ApoB, apolipoprotein B. Apolipoprotein levels are expressed in relative units compared with the levels of male Scd1+/+Ldlr−/− mice. Data represent means ± SD. The number of animals in each subgroup is indicated in parentheses.