Table 3.

Results of generalized estimating equation (GEE) models of sCD14 levels as a function of past 30-day alcohol use (Model Set 1) and alcohol use plus clinical and demographic control variables (Model Set 2).

Model Set 1: Alcohol use only	Alcohol use B (SE)	p- value
Average drinks per week	32.56 (9.50)	.001
Drinking days	79.98 (23.01)	.001
Heavy drinking days	111.64 (21.83)	< .001
Drinks per drinking day	83.41 (116.87)	.475
Days since last drink	−118.03 (24.73)	< .001
Model Set 2: Alcohol use and control variables	Alcohol use B (SE)	p- value	Age B (SE)	p- value	HIV duration B (SE)	p- value	Smoking B (SE)	p- value	CD4 nadir B (SE)	p- value	ART type B (SE)	p- value
Average drinks per week	30.10 (10.65)	.005	67.86 (74.60)	.363	−26.51 (75.09)	.724	241.68 (504.75)	.632	−1.08 (2.85)	.704	−141.06 (1035.72)	.892
Drinking days	68.08 (24.93)	.006	72.41 (68.32)	.289	−41.30 (65.84)	.531	223.47 (483.00)	.644	−1.15 (2.85)	.688	1.78 (916.71)	.998
Heavy drinking days	106.25 (24.82)	< .001	56.89 (75.51)	.451	−9.78 (76.14)	.898	62.10 (486.41)	.898	−.832 (2.86)	.771	−412.16 (993.04)	.678
Drinks per drinking day	153.43 (102.20)	.133	52.96 (83.21)	.525	−8.70 (83.61)	.917	203.89 (534.99)	.703	−0.96 (3.00)	.747	−430.00 (1194.33)	.719
Days since last drink	-126.01 (24.15)	< .001	78.53 (70.97)	.269	−17.82 (71.07)	.802	788.06 (607.89)	.195	−1.64 (3.09)	.596	−322.89 (918.66)	.725

Abbreviations: ART = antiretroviral therapy; PI = protease inhibitor.

Notes: Beta coefficients represent change in sCD14 (ng/ml) for a 1-unit change in the predictor. Categorical variables were coded as follows: smoking status, non-smoker = 0 and smoker =1; ART type, protease inhibitor-sparing ART = 0, protease inhibitor-containing ART = 1. Repeating Model Set 2 analyses with current CD4 count instead of CD4 nadir produced comparable results.