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. 2016 Aug 15;138(6):806–820. doi: 10.1111/jnc.13718

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© 2016 The Authors. Journal of Neurochemistry published by John Wiley & Sons Ltd on behalf of International Society for Neurochemistry

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Lypd6 inhibits nicotine‐induced ERK phosphorylation. (a) Pre‐incubation for 10 min with 4 μM recombinant human Lypd6 reduces nicotine‐induced ERK phosphorylation in PC12 cells, after stimulation with 25 μM nicotine for 5 min. (b) Representative images of a western blot membrane summarized in (a), where the phosphorylated isoforms p44 and p42 of the MAP kinase ERK (ERK1/2) are represented in the top panel (pERK), whereas the total amount of unphosphorylated ERK 1/2 is indicated in the bottom panel (totERK). **p < 0.01, ***p < 0.001 indicates statistical difference from the nicotine group in a one‐way ANOVA test.