Table 2.
Number of livers from carriers of SLCO1B1, ABCG2 and ABCC2 SNPs present in the studied pediatric livers (Age, 0–16 yr)
| Gene SNP ID |
Variant | Protein Amino acid change |
Number of livers (n) | ||
|---|---|---|---|---|---|
| Homozygous variant |
Heterozygous variant |
Wild- type |
|||
| SLCO1B1# | |||||
| rs2306283 | 388A>G (*1A) | N130D | 18 | 22 | 28 |
| rs11045819 | 463C>A (*4) | P155T | 2 | 13 | 54 |
| rs4149056 | 521T>C (*5) | V174A | 2 | 17 | 51 |
| ABCG2 | |||||
| rs2231142 | 421C>A | Q141K | 1 | 11 | 57 |
| ABCC2 | |||||
| rs2273697 | 1249G>A | V417I | 2 | 25 | 42 |
#
Number of livers harboring haplotype SLCO*1A/*1A, *14/*1A and *15/*1A were 12, 4 and 8, respectively.