Table 1.
Cognitive and anxiety measures of sham-irradiated and 56Fe irradiated E4, E3, and WT female mice in the water maze test.1
| Measure | Visible | Hidden | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||||
| Sham-Irradiated | Irradiated | Sham-Irradiated | Irradiated | |||||||||
| WT | E4 | E3 | WT | E4 | E3 | WT | E4 | E3 | WT | E4 | E3 | |
| Mean Cumulative Distance to target (cm) | 6648.89 ± 790.08 | 5973.12 ± 734.88 | 5514.02 ± 1080.81 | 7572.34 ± 892.13 | 6935.45 ± 732.78 | 6205.69 ± 1214.5 | 6465.46 ± 421.39 | 5963.24 ± 517.24 | 5482.66 ± 698.72 | 7479.77 ± 530.61 | 6951.99 ± 532.69 | 4447.47 ± 546.21 |
| Thigmotaxis (%) | 15.45 ± 2.05 | 13.56 ± 1.82 | 14.66 ± 3.27 | 17.16 ± 2.25 | 15.46 ± 1.99 | 9.87 ± 2.32 | 4.82 ± 0.46 | 4.86 ± 0.91 | 2.23 ± 0.42 | 6.84 ± 0.75 | 9.46 ± 1.66 | 2.96 ± 0.85 |
| Swim Speeds (cm/s) | 17.49 ± 0.36 | 17.97 ± 0.50 | 18.16 ± 0.58 | 17.78 ± 0.26 | 16.40 ± 0.27 | 17.71 ± 0.45 | 18.44 ± 0.31 | 17.51 ± 0.35 | 18.55 ± 0.33 | 18.34 ± 0.28 | 17.16 ± 0.34 | 17.89 ± 0.35 |
1
Data are shown as group averages ± SEM. N = 10–16 per group. All data were analyzed by ANOVA, using genotype and treatment as between-group factors. There were no significant effects in any outcome measure.