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. 2016 Jun 18;41(10):1960–1972. doi: 10.1007/s00261-016-0807-7

Table 2.

Characteristics of the included studies

Study Study design Patient enrollment Number of patients Number of lesions Gender ratio (m:f) Patient age: mean (range) Cirrhosis Child-pugh class A/B/C Number of HCC lesions Lesion size (cm)
Kakihara et al. Retrospective NDa 15 118 11:4 55 (45–71) Cirrhosis 0/8/7 61 1.3 (0.5–6.6)
Nishie et al. Retrospective ND 12 103 9:3 60 (46–72) Cirrhosis 0/6/6 26 1.2 (0.5–3.4)
Yoo et al. Retrospective Consecutive 33 104 27:6 53.3 (46–60) Cirrhosis 46/16/5 82 2.25 (0.3–5.1)
Di Martino et al. Prospective Consecutive 58 109 39:19 63 (35–84) Cirrhosis 30/21/7 87 1.8 (0.3–7.0)
Akai et al. Prospective Consecutive 34 CT: 74
MR: 97		 27:7 65 (48–78) Cirrhosis or not ND 52 2.6 (0.4–15.2)
Haradome et al. Retrospective Consecutive 75 99 60:15 54.7 (42–67) Cirrhosis or not 48/5/1 60 1.74 (1.09–2.39)
Baek et al. Retrospective Consecutive 51 111 43:5 (32–80) Cirrhosis 42/7/2 73 2.98 (0.2–10)
Sun et al. Retrospective ND 42 CT: 61
MR: 60		 56:13 56 (39–73) Cirrhosis ND 33 1.37 (0.96–1.78)
Kim et al. Retrospective Consecutive 62 132 54:8 55 (31–67) Cirrhosis or not 62/0/0 83 2.9 (0.5–10.5)
Sano et al. Retrospective Consecutive 64 CT: 248
MR: 253		 47:17 mb: 66 (56–75);
fc: 71 (62–80)		 Cirrhosis or not 54/10/0 96 1.27 (0.4–2)
Granito et al. Prospective Consecutive 33 48 25:8 70 (48–74) Cirrhosis 28/5/0 38 1.8 (1.0–3.0)
Park et al. Retrospective Consecutive 148 125 103:45 56 (30–73) Cirrhosis 141/5/2 102 1.3 (0.6–2.0)
Study Blindd CT or MRI read first Time interval between MRI and CT reading CT Scanner row Magnetic field strength Use pathology as the only reference standard Gd-EOB-DTPA-enhanced MR imaging Multidetector CT
Tph Fpi Fnj Tnk Tp Fp fn tn
Kakihara et al. Y CT 4 weeks 64 1.5 T Yes 20 2 16 80 15 3 21 79
Nishie et al. Y CT 4 weeks 64 3 T Yes 16 4 14 69 16 4 14 69
Yoo et al. Y CT ND 64 3 T Yes 54 2 28 20 36 1 46 21
Di Martino et al. Ye Random NDg 64 1.5 T No 74 1 13 21 60 5 27 17
Akai et al. Yf Reader 1 CT, Reader 2 MR >2 weeks 64 1.5 T Yes 45 4 7 41 41 3 12 18
Haradome et al. Ye CT 3 weeks 16 1.5 T No 52 3 8 36 42 2 18 37
Baek et al. Y Random ND 64, 16, 4 3 T No 65 2 8 34 56 2 17 36
Sun et al. Y MR 2 weeks 64, 16, 8 3 T No 30 2 3 25 18 1 15 27
Kim et al. Y Random 4 weeks 64, 40, 16 3 T Yes 77 2 6 47 74 3 9 46
Sano et al. Y Random >1 weeks 16 1.5 T Yes 87 8 4 154 58 3 29 158
Granito et al. Y ND ND 6, 16 1.5 T No 38 3 0 7 22 0 16 10
Park et al. Y CT ND 64, 40 3 T No 100 3 2 20 64 1 38 22

This table provides details of all the studies included in this research, from clinical information to imaging information

aNo data

bMale

cFemale

dImage readers were blinded to patient’s histories, laboratory results, findings of other imaging techniques, and final diagnosis

eImage readers were aware of patients’ history of cirrhosis and that patients had been suspected of HCC

fImage readers were aware that patients were suspected of HCC

gReading session interval (where MR and CT images were mixed in a random order in one session) > 4 weeks

hTrue positive. The number in this column refers to the number of true-positive lesions

iFalse positive. The number in this column refers to the number of false-positive lesions

jFalse negative. The number in this column refers to the number of false-negative lesions

kTrue negative. The number in this column refers to the number of true-negative lesions