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Synthetic multivalent glycopolymers were designed to elucidate the role of receptor clustering in the modulation of B-cell responses. The displayed dinitrophenyl hapten induced BCR complex formation to activate signaling, whereas the sialoglycan ligands recruited the CD22 co-receptor to suppress B-cell responses (adapted from Courtney et al. 2009). This figure is available in black and white in print and in color at Glycobiology online.
