Table 2.

Multivariate Cox regression model evaluating the impact of cancer staging, tobacco, alcohol consumption, HPV status and response to CCRT on progression-free survival (PFS), or overall survival (OS)

	Factors	HR	95 % CI	p value
PFS	Stage (II/III vs. IV)	1.78	1.17–2.71	<0.01
	Tobacco (non-smokers vs. smokers)	1.22	0.86–1.74	0.26
	Alcohol (nondrinkers vs. drinkers)	1.72	1.09–2.71	0.02
	HPV status (HPV− vs. active HPV+)	0.96	0.49–1.89	0.91
	Response to CCRT (no vs. yes)	3.38	2.40–4.78	<0.01
OS	Stage (II/III vs. IV)	1.60	0.99–2.59	0.05
	Tobacco (non-smokers vs. smokers)	1.51	1.03–2.22	0.03
	Alcohol (nondrinkers vs. drinkers)	2.27	1.34–3.86	<0.01
	HPV status (HPV− vs. active HPV+)	1.24	0.59–2.64	0.57
	Response to CCRT (no vs. yes)	2.93	2.01–4.29	<0.01