Table 3.
List of the studies reporting a positive impact of HPV on the response to chemoradiotherapy in HNSCCs
| First author (year) | Number of patients | HPV prevalence (%) | Anatomical site | Smokers (n) | Drinkers (n) | Detection methods of HPV |
|---|---|---|---|---|---|---|
| Kumar et al. (2007) | 42 | 64 | Oropharynx | 34 | Not listed | qPCR |
| Chung et al. (2009) | 46 | 50 | Oropharynx | Not listed | Not listed |
PCR In situ hybridization |
| Nichols et al. (2009) | 44 | 61 | Oropharynx | Not listed | Not listed | In situ hybridization |
| Fallai et al. (2009) | 78 | 11 | Oropharynx | Not listed | Not listed | qPCR |
| de Jong et al. (2010) | 75 | 49 |
Pharynx Oral cavity |
Not listed | Not listed | Genetic signature |
| Rischin et al. (2010) | 172 | 65 | Oropharynx | 111 | Not listed |
PCR In situ hybridization |
| Hong et al. (2010) | 35 | 24 | Head and neck squamous cell carcinomas | Not listed | Not listed | qPCR |
| Ang et al. (2010) | 323 | 64 | Oropharynx | 68 | Not listed |
In situ hybridization p16 immunohistochemistry |
| Lill et al. (2011) | 29 | 38 | Head and neck squamous cell carcinomas | Not listed | Not listed |
PCR In situ hybridization |
| Hasegawa et al. (2014) | 39 | 41 | Oropharynx | 16 | 33 |
PCR p16 immunohistochemistry |
| Flavill et al. (2014) | 49 | 73 | Oropharynx | 28 | 12 |
PCR p16 immunohistochemistry |