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. 2016 Jun 15;116(3):1208–1217. doi: 10.1152/jn.00369.2016

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Fig. 1. — Induction of long-term depression (LTD) in the parallel fiber to Purkinje cell (PC) synapse results in an increase of intrinsic excitability. A, top: representative excitatory postsynaptic currents (EPSCs) measured before (pre) and after (post) LTD induction. Bottom, summary graph showing the EPSC amplitude reduction in LTD (n = 12) and control (n = 4) groups. B, top: representative action potential (AP) traces to the same input current before (pre) and after (post) LTD induction. Bottom, firing rate versus injected current curves for the same cell (fits ± 95% confidence intervals). C, top: average firing rate response before (pre) and after (post) LTD induction (n = 12). Bottom, change in firing rate for all experimental groups. Values are means ± SE; control: n = 9; only somatic depolarization (DEP): n = 10; only parallel fiber stimulation (PF): n = 7. Average of fits to the LTD group showed a slope of ΔG = 0.05 ± 0.01 Hz/pA. *P < 0.05.