Table 1.
Protein thiol oxidation of abundant proteins in healthy and GRMD muscle. Asterisks represent significant differences of p<0.05. Data are presented as mean±SEM and n=4 and 5 for healthy and GRMD dogs respectively.
| Protein name | Accession # | # Sig. peptides | Healthy dogs | GRMD dogs |
|---|---|---|---|---|
| Myosin | Q076A6 | 8 | 11.0±1.5 | 30.8±3.8* |
| Myosin-binding protein C | Q00872 | 18 | 17.5±0.9 | 34.0±2.9* |
| Sarcoplasmic/reticulum calcium ATPase | O14983 | 9 | 15.3±0.8 | 30.5±2.8* |
| Lactoferrin | P02788 | 26 | 27.3±2.6 | 65.7±4.6* |
| Albumin | P49822 | 33 | 13.0±0.8 | 31.7±3.0* |
| Phosphoglucomutase | Q08DP0 | 5 | 12.9±0.8 | 31.0±2.8* |
| Pyruvate kinase | P11980 | 5 | 11.2±0.8 | 24.0±1.8* |
| Myotilin | Q9UBF9 | 8 | 12.8±1.0 | 25.8±2.5* |
| Glyceraldehyde-3-phosphate dehydrogenase | Q28259 | 13 | 10.0±1.3 | 15.2±1.7* |
| Malate dehydrogenase | P08249 | 8 | 8.6±0.9 | 18.7±2.3* |
| Alpha actin | P68138 | 87 | 4.7±0.6 | 5.5±0.6 |
| Creatine kinase | P05123 | 47 | 8.6±0.9 | 8.6±0.9 |