Table 2.
Summary of differences in GRMD tissues (compared with normal control dogs).
| Parameter measured | Increase ↑ or decrease ↓ | Fold change |
|---|---|---|
| Inflammation in muscle | ||
| Neutrophils | ↑ | 35 |
| Macrophages | ↑ | 9 |
| Oxidative stress in muscle | ||
| MPO | ↑ | 33 |
| HOCL | ↑ | 1.4 |
| Total protein thiols | ↓ | -1.3 |
| % Total protein thiol oxidation | ↑ | 2.8 |
| Thiol oxidation in 10/12 specific proteins | ↑ | ~2 |
| Protein carbonylation | ↑ | 1.4 |
| Taurine metabolism | ||
| Muscle taurine | ↑ | 4.7 |
| Plasma taurine | ↓ | −1.4 |
| Muscle TauT | ↑ | 12 |
| Muscle cysteine deoxygenase | ↑ | 8 |
| Muscle cysteine decarboxylase | ↑ | 35 |