Figure 1.

An overview of the experimental setup and data simulation. (A) Experimental setup: linear array mounted on a high-precision translation stage, attached to a rotation platform. The transducer is connected to a specially designed holder, tilting the length axis to 45 angular degrees, providing access to the sample under investigation. RS, rotation stage; TS, translation stage; AP, adapting plate; LR, linear array. (B) Schematic of the implantation sites of tumors in a mouse (top) with a view of the mouse holder (MH) and the four fiber bundles (FB) delivering the illumination to the tumor (Tu) (bottom). Arrow with dashed line indicates the rotation trajectory of the linear array, while red arrowheads depict the translation motion. (C) Simulated results of 10-μm microspheres with different tilting angles of the transducer (0°, 30°, and 45°): an aerial view (xy plane) and side view (xz plane). (D) Graphical representation of the relationship between the encompassed volume of the sample and angular tilting of the array (blue dashed curve) and standard deviation of the 3D resolution (black curve). (E, F) Simulated configuration of a center absorber (suture; 100-μm diameter) with the first (red) and last (blue) detector positions in a tomographic scan varying the angular tilting of the transducer with reconstructed images along the xz plane depicting the absorber for 0°, 30°, and 45° tilting of the array. AS, absorbing suture; S, starting; E, ending degrees.