Figure 8.

Models of flNaPi-IIb in outward- and inward-facing open conformations. The protein is represented in cartoon; and the Na⁺ atoms, i.e., the P_i and Cα atoms of residues Ala-104, Ala-116, and Ser-155, are shown in purple, green/red, green, yellow, and red spheres, respectively. Domains were assigned according to the VcINDY template, and depicted with the transport domain colored orange, and the scaffold (or oligomerization domain in blue). The exposure and I^– quenching of fluorophores at Ala-104, Ala-116, and Ser-155 is indicated for each of the conformations. To see this figure in color, go online.