Figure 5.

Verification of the assumptions and predictions of the theory using atomistic simulations (see Piana et al. (34)). (a) For ∼50% of the transition-path (TP) duration, more than two native-like segments are formed in the largest structured region. (b) Histograms of the number of distinct structured regions with a minimum number of residues in the transition-path ensemble. (c) The fraction of the total transition-path time spent in each topological configuration. (d) The mean, τ, versus standard deviation, σ, of the topological-configuration lifetimes. The line σ = τ is indicative of an exponential waiting-time distribution. To see this figure in color, go online.