Figure 2.

Proper SAC silencing requires inverse correlation between spindle length and aspect ratio. (A) Criteria for robust and timely SAC silencing in model results. For the given threshold signal (400 times bulk concentration), the final steady-state signal has to be at least 15% above threshold and the penultimate steady-state signal at least 15% below threshold. (B) Examples of aberrancies in SAC silencing. Premature SAC silencing may result either from signals being too high (left panels) or insufficient jump ratio (upper-right panel). SAC silencing is inhibited if the signal is too low (lower-right panel). (C) Phase diagram of the SAC silencing behavior given spindle length and aspect ratio (i.e., spindle width/spindle length). Categorization of the simulation results follows the rules illustrated in (A) and (B).