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. 2016 Sep 6;111(5):963–972. doi: 10.1016/j.bpj.2016.04.055

Figure 6.

Figure 6

Stereo view of the cytoplasmic half-channel of D217E ASR. A network of ordered waters and polar residues connects the Lys210 carbonyl with Glu217, which is protonated upon formation of the M intermediate of D21E ASR. The placement of the Glu217 carboxyl has replaced Wat505. Furthermore, Wat503 is displaced, forming a hydrogen bond with the Ser214 hydroxyl. Glu36, protonated in the L intermediate, is located near the cytoplasmic surface along with Gln93, and may serve as a proton gate, as well as the site of proton release into the cytoplasm. To see this figure in color, go online.