Table 1.
Rapalog-induced mitophagy
| Cell Type | rap | Avg. % | Fold Change | ||
|---|---|---|---|---|---|
| WT | Vector | − | 1.15 | − | |
| + | 8.37 | 7.28 | |||
| OPTN | − | 1.08 | − | ||
| + | 8.59 | 7.95 | |||
| pentaKO | Vector | − | 0.93 | − | |
| + | 0.99 | 1.06 | |||
| OPTN | − | 0.89 | − | ||
| + | 4.83 | 5.43 | |||
| pentaKO | PINK1-WT | Vector | + | 1.13 | − |
| OPTN | + | 5.27 | 4.66 | ||
| PINK1-KD | Vector | + | 0.88 | 0.78 | |
| OPTN | + | 0.76 | 0.67 | ||
| pentaKO+NDP52 | − | + | 0.87 | − | |
| WT | + | 3.50 | 3.98 | ||
| V248A | + | 2.80 | 3.18 | ||
| ΔZF | + | 0.47 | 0.53 | ||
| pentaKO | p62 | + | 1.23 | 1.36 | |
| pentaKO+OPTN | − | + | 0.93 | − | |
| WT | + | 2.97 | 3.19 | ||
| E50K | + | 15.8 | 17.0 | ||
| S177A | + | 2.57 | 2.76 | ||
| Q398X | + | 0.87 | 0.78 | ||
| D474N | + | 0.76 | 0.67 | ||
| pentaKO+OPTN | − | − | 1.10 | − | |
| − | + | 5.30 | 4.81 | ||
| Parkin | − | 1.43 | − | ||
| Parkin | + | 23.60 | 16.50 | ||