Table 3.

Likelihood of acute toxicity in patients receiving CTRT vs. RT

Toxicity	Adjusted Odds Ratio (95% CI)	p-value
Any toxicity	2.10 (1.72, 2.56)	<0.0001
By diagnostic category
Oral	1.84 (1.46, 2.32)	<0.0001
Gastrointestinal	3.47 (2.16, 5.58)	<0.0001
Dehydration	2.40 (1.64, 3.51)	<0.0001
Hematologic	3.11 (2.41, 4.01)	<0.0001
Infection	1.32 (1.05, 1.67)	0.0171
Fever	2.70 (1.48, 4.94)	0.0012
Acute renal failure	1.95 (1.29, 2.96)	0.0016
Cardiac	0.99 (0.76, 1.28)	NS
PE/DVT	2.65 (1.45, 4.85)	0.0015
Other	3.76 (2.14, 6.62)	<0.0001

Notes: Odds ratios adjusted for age, sex, race, median income, urban residence, geographic region, marital status, SEER historical stage, Charlson comorbidity index and year of diagnosis.

Acute toxicity was defined as any hospitalization or ER visit for a primary or secondary diagnosis within the specified category suggestive of an adverse effect of chemotherapy or RT within 6 months of a patient’s first treatment claim.

Examining the impact of treatment (CTRT vs. RT) on the odds of any toxicity-related hospitalization or ER visit, showed an increased risk with older age at diagnosis (p=0.02) and greater comorbidity (p<0.0001).

Abbreviations: CTRT, chemoradiation; RT, radiation; GI, gastrointestinal; PE/DVT, pulmonary embolism/deep vein thrombosis; CI, confidence interval; OR, odds ratio; NS: Not statistically significant at p<0.05.